2-Chlorophenylboronic acid → HCID 67396737, compound

HRID 714643Notes

Reaction equation

HRID 714643 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1B(O)O>>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][N:11]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 38477682-Bromo-isonicotinic acid methyl ester

Product 1

HCID 67396737HCID 67396737, compound

Procedure

500 mg (2.31 mmol) of methyl 2-bromoisonicotinate and 597 mg (3.47 mmol) of 2-chlorophenylboronic acid were reacted with one another analogously to the process of Example 58A. This gave 323 mg (56% of theory) of the target compound.

Sources & evidence

ORD record
ord-e8e696b61029419a859e3d59797a9e09
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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