Potassium Phosphate, Tribasic → HCID 21025895, compound

Participants

Reaction Conditions

Reaction Steps

Under an atmosphere of argon, 250 mg (1.95 mmol) of 2-chloro-4-methylpyrimidine and 583 mg (2.92 mmol) of 2-(trifluoromethyl)phenylboronic acid were dissolved in 8 ml of toluene. 89 mg (0.10 mmol) of tris(dibenzylideneacetone)dipalladium, 77 mg (0.19 mmol) of 2-dicyclohexyl-phosphino-2′-(N,N-dimethylamino)biphenyl and 826 mg (3.89 mmol) of potassium phosphate were then added, and under argon the mixture was heated at 110° C. for 20 h. For work-up, the mixture was diluted at RT with 15 ml of ethyl acetate and 15 ml of water, the organic phase was separated off and the aqueous phase extracted two more times with in each case 15 ml of ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified chromatographically on silica gel (mobile phase: cyclohexane/ethyl acetate 9:1, then 4:1). This gave 249 mg (54% of theory) of the target compound in a purity of 87%.

Provenance & Evidence