反应详情

1.04 g (4.41 mmol) of 5-(4-chlorophenyl)-4-cyclopropyl-2,4-dihydro-3H-1,2,4-triazol-3-one [preparation according to WO 2007/134862 Example 36A] and 2.16 g (6.62 mmol) of cesium carbonate were suspended in 35 ml of acetonitrile, and 1.32 g (5.30 mmol) of 2-bromobenzyl bromide were added. The mixture was stirred under reflux for 18 h. The precipitated solid was then filtered off and the filtrate was concentrated under reduced pressure. The solid that remained was stirred in about 50 ml of diethyl ether and then filtered off and washed with a little diethyl ether. Drying under reduced pressure gave 1.05 g (59% of theory) of the target compound as a white solid.

1. temperatureunder reflux for 18 h
2. filtrationThe precipitated solid was then filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. stirringThe solid that remained was stirred in about 50 ml of diethyl ether
5. filtrationfiltered off
6. washwashed with a little diethyl ether
7. customDrying under reduced pressure