反应详情

400 mg (1.30 mmol) of the compound from Example 4A and 635 mg (1.95 mmol) of cesium carbonate were suspended in 3 ml of acetonitrile, and 357 mg (1.43 mmol) of 3-bromobenzyl bromide were added. The mixture was stirred under reflux for 20 h. The precipitated solid was then filtered off, and the filtrate was concentrated under reduced pressure to a volume of about 1.5 ml and directly purified chromatographically [Method 19]. This gave 507 mg (82% of theory) of the target compound.

1. temperatureunder reflux for 20 h
2. filtrationThe precipitated solid was then filtered off
3. concentrationthe filtrate was concentrated under reduced pressure to a volume of about 1.5 ml
4. customdirectly purified chromatographically [Method 19]