2-Chlorophenylboronic acid → HCID 67396396, compound

HRID 714663Notes

Reaction equation

HRID 714663 reaction equation
Br[C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O>>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:2]1[C:3]([C:4]([O:6][CH3:7])=[O:5])=[CH:8][CH:9]=[C:10]([CH3:12])[CH:11]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 21779704Methyl 2-bromo-4-methylbenzoate

Product 1

HCID 67396396HCID 67396396, compound

Procedure

500 mg (2.18 mmol) of methyl 2-bromo-4-methylbenzoate and 512 mg (3.27 mmol) of 2-chlorophenylboronic acid were reacted analogously to the preparation of Example 107A. This gave 275 mg (48% of theory) of the target compound.

Sources & evidence

ORD record
ord-d37f47863e1b4b748bef1a937df91154
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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