Water → HCID 53378621, compound

Participants

Reaction Steps

50 mg (0.13 mmol) of the compound from Example 7A were dissolved in 2 ml of toluene, 51 mg (0.28 mmol) of (1Z)-2-(2-chlorophenyl)-N′-hydroxyethaneimidamide and 38 mg (0.28 mmol) of potassium carbonate were added and the mixture was heated under reflux for 6 h. For work-up, 10 ml of water were added and the mixture was extracted twice with in each case 10 ml of ethyl acetate. The combined organic phases were washed once with 10 ml of water and 10 ml of saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified chromatographically [Method 19]. This gave 40 mg (59% of theory) of the target compound.

Provenance & Evidence