HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → HCID 178497762, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-[2-(Trifluoromethyl)phenyl]ethaneimidamide hydrobromide | HCID 67396542 | — |
| Reactant | Methyl 3-{[3-(4-chlorophenyl)-1-(2-hydrazino-2-oxoethyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]methyl}benzenecarboxylate | HCID 69940030 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178497762 | HCID 178497762 | — |
Reaction Steps
77 mg (0.27 mmol) of 2-[2-(trifluoromethyl)phenyl]ethaneimidamide hydrobromide were dissolved in 1 ml of dry methanol, 74 μl (0.27 mmol) of a 25% strength methanolic sodium methoxide solution were added and the mixture was stirred for 30 min 75 mg (0.18 mmol) of the compound from Example 16A were then added, and the mixture was stirred initially at RT for 16 h and then under reflux for 5 h. The mixture was then directly purified chromatographically [Method 19]. This gave 67 mg (64% of theory) of the target compound as a colorless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187466B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-28b9a73569e54cbaaf95393077f47b5f |
| Source note | uspto-grants-2015_11 |