HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714684Generated: October 29, 2026
Sodium Methoxide → HCID 178440342, compound
https://huagongshe.com/reaction/714684
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-(2-Fluorophenyl)-2-methylpropaneimidamide hydrochloride | HCID 67396731 | — |
| Reactant | 2-[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide | HCID 67406141 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178440342 | HCID 178440342 | — |
Reaction Steps
60 mg (0.20 mmol) of the compound from Example 21A were dissolved in 1 ml of DMF, and 63 mg (0.29 mmol) of 2-(2-fluorophenyl)-2-methylpropaneimidamide hydrochloride and 17 mg (0.31 mmol) of sodium methoxide were added. The suspension was stirred at 150° C. for 8 h. The reaction was then brought to completion by 45 min of stirring in a microwave reactor at 200° C. The suspension was diluted with about 1 ml of methanol and filtered, and the filtrate was purified by preparative HPLC [Method 19]. This gave 13 mg (15% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187466B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-fa4c50d5bee14c8d93a7e82dc29c60b5 |
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| Source note | uspto-grants-2015_11 |
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