Cesium carbonate → HCID 86690921, compound

Participants

Role	Name	HCID	Charge
Reactant	Cesium carbonate	HCID 10796	—
Reactant	5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one	HCID 59536836	—
Reactant	HCID 67410302	HCID 67410302	—
Solvent	Methanol	HCID 887	—
Solvent	Acetonitrile	HCID 6342	—
Product	HCID 86690921	HCID 86690921	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

40 mg (0.13 mmol) of the compound from Example 5A were dissolved in 7 ml of acetonitrile, and 66 mg (0.20 mmol) of cesium carbonate and 42 mg (0.13 mmol) of the compound from Example 89A were added. The mixture was stirred at 80° C. for 1 h. For work-up, the mixture was cooled to RT, diluted with 5 ml of methanol and filtered. The filtrate was concentrated under reduced pressure and the crude product was then purified chromatographically [Method 19]. This gave 47 mg (66% of theory) of the target compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09187466B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-b5cc0332442743bfbe7b02d63f0d5aa2
Source note	uspto-grants-2015_11