HCID 59187443, compound → HCID 69940395, compound

HRID 714691Notes

Reaction equation

HRID 714691 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[S:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:34])=[CH:26][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:10](=[O:13])[N:11]([CH2:22][C:23]3[S:24][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[Cl:34])=[CH:26][N:27]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 59187443HCID 59187443, compoundHCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Product 1

HCID 69940395HCID 69940395, compound

Procedure

70 mg (0.23 mmol) of the compound from Example 5A were reacted with 66 mg (0.23 mmol) of the compound from Example 88A analogously to the preparation of the compound in Example 77. This gave 65 mg (55% of theory) of the title compound.

Sources & evidence

ORD record
ord-fade3bd00de54148b8d8c76680100ce2
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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