5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 86690922, compound

HRID 714692Notes

Reaction equation

HRID 714692 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[S:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:29]=2[F:35])=[CH:26][N:27]=1>>[Cl:34][C:30]1[C:29]([F:35])=[C:28]([C:25]2[S:24][C:23]([CH2:22][N:11]3[C:10](=[O:13])[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)=[N:12]3)=[N:27][CH:26]=2)[CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67410404HCID 67410404, compound

Product 1

HCID 86690922HCID 86690922, compound

Procedure

70 mg (0.23 mmol) of the compound from Example 5A were reacted with 70 mg (0.23 mmol) of the compound from Example 90A analogously to the preparation of the compound in Example 77. This gave 90 mg (72% of theory) of the title compound.

Sources & evidence

ORD record
ord-de5c903ee5844c44afec664d3f7493a1
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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