5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 86690923, compound

HRID 714693Notes

Reaction equation

HRID 714693 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[S:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[C:29]=2[F:38])=[CH:26][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:10](=[O:13])[N:11]([CH2:22][C:23]3[S:24][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[C:29]=4[F:38])=[CH:26][N:27]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67397320HCID 67397320, compound

Product 1

HCID 86690923HCID 86690923, compound

Procedure

55 mg (0.18 mmol) of the compound from Example 5A were reacted with 61 mg (0.18 mmol) of the compound from Example 91A analogously to the preparation of the compound in Example 77. This gave 55 mg (52% of theory) of the title compound.

Sources & evidence

ORD record
ord-29df541a6f484fa3b4bfba96fb5420c6
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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