5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 67408238, compound

HRID 714695Notes

Reaction equation

HRID 714695 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[O:27][C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:34])=[N:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:10](=[O:13])[N:11]([CH2:22][C:23]3[O:27][C:26]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[Cl:34])=[N:25][CH:24]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67406907HCID 67406907, compound

Product 1

HCID 67408238HCID 67408238, compound

Procedure

113 mg (0.37 mmol) of the compound from Example 5A were reacted with 100 mg (0.37 mmol) of the compound from Example 54A analogously to the preparation of the compound in Example 77. This gave 23 mg (12% of theory) of the title compound.

Sources & evidence

ORD record
ord-72c78c332f3947b597b76093f92bdf31
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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