5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 53378840, compound

HRID 714696Notes

Reaction equation

HRID 714696 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[O:27][C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:29]=2[Cl:35])=[N:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:10](=[O:13])[N:11]([CH2:22][C:23]3[O:27][C:26]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:29]=4[Cl:35])=[N:25][CH:24]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 69940385HCID 69940385, compound

Product 1

HCID 53378840HCID 53378840, compound

Procedure

49 mg (0.16 mmol) of the compound from Example 5A were reacted with 49 mg (0.16 mmol) of the compound from Example 55A analogously to the preparation of the compound in Example 77. This gave 35 mg (40% of theory) of the title compound.

Sources & evidence

ORD record
ord-7f2bef07a89a49d18f50ddd0ec4a981a
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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