HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorophenylboronic acid → 5-(4-Chlorophenyl)-2-{[5-(2-chlorophenyl)pyridin-3-yl]methyl}-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorophenylboronic acid | HCID 2734322 | — |
| Reactant | 2-[(5-Bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-di-hydro-3H-1,2,4-triazol-3-one | HCID 67408667 | — |
| Product | 5-(4-Chlorophenyl)-2-{[5-(2-chlorophenyl)pyridin-3-yl]methyl}-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 53378841 | — |
Reaction Steps
Analogously to the preparation of the compound in Example 86, 72 mg (0.15 mmol) of the compound from Example 28A and 59 mg (0.23 mmol) of 2-chlorophenylboronic acid were reacted with one another. This gave 49 mg (64% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187466B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-88794f1de0e64855bdb965f5181a7b99 |
| Source note | uspto-grants-2015_11 |