HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichlorobenzeneboronic acid → 5-(4-Chlorophenyl)-2-{[5-(2,3-dichlorophenyl)pyridin-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichlorobenzeneboronic acid | HCID 2734661 | — |
| Reactant | 2-[(5-Bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 67397223 | — |
| Product | 5-(4-Chlorophenyl)-2-{[5-(2,3-dichlorophenyl)pyridin-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 86690926 | — |
Reaction Steps
Analogously to the preparation of the compound in Example 86, 34 mg (0.07 mmol) of the compound from Example 29A and 20 mg (0.10 mmol) of 2,3-dichlorophenylboronic acid were reacted with one another. This gave 26 mg (69% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187466B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ea2bd653bcda4296b66795a573444988 |
| Source note | uspto-grants-2015_11 |