HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714703Generated: November 1, 2026
Cesium carbonate → HCID 86690928, compound
https://huagongshe.com/reaction/714703
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 59536836 | — |
| Reactant | HCID 67398997 | HCID 67398997 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86690928 | HCID 86690928 | — |
Reaction Steps
81 mg (0.26 mmol) of the compound from Example 66A were dissolved in 3 ml of acetonitrile and 79 mg (0.26 mmol) of the compound from Example 5A and 125 mg (0.38 mmol) of cesium carbonate were added. The mixture was stirred at 65° C. for 2 h and at RT for a further 16 h. The solid was then filtered off and rinsed with a little acetonitrile. The filtrate was concentrated under reduced pressure and directly purified chromatographically [Method 19]. This gave 79 mg (56% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09187466B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-da7df0f259ce43cb92018588223c0b15 |
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| Source note | uspto-grants-2015_11 |
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