Cesium carbonate → HCID 86690929, compound

Participants

Reaction Conditions

Reaction Steps

303 mg (0.19 mmol) of the compound from Example 80A (purity about 20%) were dissolved in 2 ml of acetonitrile, and 65 mg (0.21 mmol) of the compound from Example 5A and 93 mg (0.29 mmol) of cesium carbonate were added. The mixture was stirred at 60° C. for 2.5 h and at RT for a further 96 h. The solid was then filtered off and rinsed with a little acetonitrile. The filtrate was concentrated under reduced pressure and directly purified chromatographically [Method 19]. This gave 19 mg of the target compound, which were subjected to a further chromatographic purification on silica gel (mobile phase: cyclohexane/ethyl acetate 7:3, then 1:1). This gave 8 mg (7% of theory) of the target compound.

Provenance & Evidence