5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 69940709, compound

HRID 714707Notes

Reaction equation

HRID 714707 reaction equation
Br[CH2:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[N:6]=[CH:5][N:4]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[N:24]([CH2:29][C@H:30]([OH:35])[C:31]([F:34])([F:33])[F:32])[C:25](=[O:28])[NH:26][N:27]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[N:24]([CH2:29][C@H:30]([OH:35])[C:31]([F:33])([F:34])[F:32])[C:25](=[O:28])[N:26]([CH2:2][C:3]3[CH:8]=[C:7]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[Cl:15])[N:6]=[CH:5][N:4]=3)[N:27]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67399030HCID 67399030, compound

Product 1

HCID 69940709HCID 69940709, compound

Procedure

Analogously to the preparation of the compound in Example 94, 27 mg (0.10 mmol) of the compound from Example 83A and 32 mg (0.11 mmol) of the compound from Example 5A were reacted with one another. This gave 29 mg (54% of theory) of the target compound.

Workup

  1. customwere reacted with one another

Sources & evidence

ORD record
ord-f63a34b56e824eae9fe59245ac5a5951
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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