5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 86690931, compound

HRID 714708Notes

Reaction equation

HRID 714708 reaction equation
Br[CH2:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])[N:6]=[CH:5][N:4]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:25]([CH2:30][C@H:31]([OH:36])[C:32]([F:35])([F:34])[F:33])[C:26](=[O:29])[NH:27][N:28]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:25]([CH2:30][C@H:31]([OH:36])[C:32]([F:34])([F:35])[F:33])[C:26](=[O:29])[N:27]([CH2:2][C:3]3[CH:8]=[C:7]([C:9]4[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=4[Cl:16])[N:6]=[CH:5][N:4]=3)[N:28]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67398454HCID 67398454, compound

Product 1

HCID 86690931HCID 86690931, compound

Procedure

Analogously to the preparation of the compound in Example 94, 23 mg (0.07 mmol) of the compound from Example 84A and 24 mg (0.08 mmol) of the compound from Example 5A were reacted with one another. This gave 29 mg (66% of theory) of the target compound.

Workup

  1. customwere reacted with one another

Sources & evidence

ORD record
ord-39f0041afd0c4a8fb87d906971be9388
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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