HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)benzeneboronic acid → 5-(4-Chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-{[2'-(trifluoromethyl)biphenyl-3-yl]-methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)benzeneboronic acid | HCID 2734387 | — |
| Reactant | 2-(3-Bromobenzyl)-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 69939743 | — |
| Product | 5-(4-Chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2-{[2'-(trifluoromethyl)biphenyl-3-yl]-methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 86690937 | — |
Reaction Steps
Analogously to the preparation of Example 122, 72 mg (0.15 mmol) of the compound from Example 101A were reacted with 43 mg (0.23 mmol) of 2-(trifluoromethyl)phenylboronic acid. This gave 49 mg (58% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187466B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-94edc3be9e8e4952a51722404182d8ac |
| Source note | uspto-grants-2015_11 |