2,3-Dichlorobenzeneboronic acid → HCID 86690938, compound

HRID 714729Notes

Reaction equation

HRID 714729 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][N:6]1[C:10](=[O:11])[N:9]([CH2:12][C@H:13]([OH:18])[C:14]([F:17])([F:16])[F:15])[C:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7]1.[Cl:29][C:30]1[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][C:31]=1B(O)O>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:8]2[N:9]([CH2:12][C@H:13]([OH:18])[C:14]([F:17])([F:16])[F:15])[C:10](=[O:11])[N:6]([CH2:5][C:4]3[CH:3]=[C:2]([C:34]4[CH:33]=[CH:32][CH:31]=[C:30]([Cl:29])[C:35]=4[Cl:36])[CH:28]=[CH:27][CH:26]=3)[N:7]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27346612,3-Dichlorobenzeneboronic acidHCID 69940343HCID 69940343, compound

Product 1

HCID 86690938HCID 86690938, compound

Procedure

Analogously to the preparation of Example 122, 94 mg (0.20 mmol) of the compound from Example 102A were reacted with 56 mg (0.23 mmol) of 2,3-dichlorophenylboronic acid. This gave 48 mg (45% of theory) of the target compound.

Sources & evidence

ORD record
ord-569eecf204e944d0b372dd1aefc87525
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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