HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)benzeneboronic acid → 5-(4-Chlorophenyl)-2-{[5-fluoro-2'-(trifluoromethyl)biphenyl-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)benzeneboronic acid | HCID 2734387 | — |
| Reactant | 2-(3-Bromo-5-fluorobenzyl)-5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 86690914 | — |
| Product | 5-(4-Chlorophenyl)-2-{[5-fluoro-2'-(trifluoromethyl)biphenyl-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 86690939 | — |
Reaction Steps
Analogously to the preparation of Example 122, 59 mg (0.12 mmol) of the compound from Example 103A were reacted with 36 mg (0.18 mmol) of 2-(trifluoromethyl)phenylboronic acid. This gave 43 mg (64% of theory) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187466B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b6d20f2fd17340c8a6c393e7e63bc5f9 |
| Source note | uspto-grants-2015_11 |