Lithium Hydroxide → HCID 53379068, compound

Participants

Reaction Steps

204 mg (0.36 mmol) of the compound from Example 129 were dissolved in 3 ml of THF, and 0.4 ml of a 1 N aqueous lithium hydroxide solution was added. The mixture was stirred at RT for 20 h. For work-up, the solvent was removed under reduced pressure, the residue was taken up in about 5 ml of water and 0.07 ml of 6 N hydrochloric acid was added. The precipitated solid was filtered off with suction and dried. Further purification of the crude product was carried out by chromatography on silica gel (mobile phase: first cyclohexane/ethyl acetate 1:3, then pure ethyl acetate, finally dichloromethane/methanol 1:1). This gave 97 mg (47% of theory) of the target compound.

Provenance & Evidence