Sodium Hydroxide → HCID 69939974, compound

HRID 714745Notes

Reaction equation

HRID 714745 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:35]([O:37]C)=[O:36])=[CH:10][CH:11]=[C:12]([CH2:14][N:15]2[C:19](=[O:20])[N:18]([CH2:21][C@H:22]([OH:27])[C:23]([F:26])([F:25])[F:24])[C:17]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)=[N:16]2)[CH:13]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:35]([OH:37])=[O:36])=[CH:10][CH:11]=[C:12]([CH2:14][N:15]2[C:19](=[O:20])[N:18]([CH2:21][C@H:22]([OH:27])[C:23]([F:24])([F:25])[F:26])[C:17]([C:28]3[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=3)=[N:16]2)[CH:13]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69940401HCID 69940401, compound

Product 1

HCID 69939974HCID 69939974, compound

Procedure

Analogously to the preparation of Example 141, 218 mg (0.39 mmol) of the compound from Example 140 were reacted with 2 N aqueous sodium hydroxide solution. This gave 220 mg (quant.) of the target compound.

Sources & evidence

ORD record
ord-3b280794417e466fb91664c6ae29d402
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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