Sodium Hydroxide → HCID 69940532, compound

HRID 714749Notes

Reaction equation

HRID 714749 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[C:12]([CH2:14][N:15]2[C:19](=[O:20])[N:18]([CH2:21][C@H:22]([OH:27])[C:23]([F:26])([F:25])[F:24])[C:17]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)=[N:16]2)[CH:11]=[C:10]([C:35]([O:37]C)=[O:36])[CH:9]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[C:12]([CH2:14][N:15]2[C:19](=[O:20])[N:18]([CH2:21][C@H:22]([OH:27])[C:23]([F:26])([F:25])[F:24])[C:17]([C:28]3[CH:29]=[CH:30][C:31]([Cl:34])=[CH:32][CH:33]=3)=[N:16]2)[CH:11]=[C:10]([C:35]([OH:37])=[O:36])[CH:9]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69940339HCID 69940339, compound

Product 1

HCID 69940532HCID 69940532, compound

Procedure

Analogously to the preparation of Example 141, 244 mg (0.43 mmol) of the compound from Example 146 were reacted with 2 N aqueous sodium hydroxide solution. This gave 242 mg (100% of theory) of the target compound.

Sources & evidence

ORD record
ord-8ecb001520e54bcb87ce8940a2fdbb5a
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

Loading…