Hydrogen Peroxide → HCID 89582530, compound

Participants

Reaction Conditions

Reaction Steps

(6-Methoxypyridazin-3-yl)pyridin-3-ylacetonitrile (7.7 g, 0.034 mol) were dissolved in acetonitrile (200 ml) at 23° C. under a nitrogen atmosphere, and potassium tert-butoxide (4.16 g, 0.037 mol) was added. The suspension was stirred at 23° C. for 30 minutes, cooled to −4° C., and hydrogen peroxide (30% solution, 11.34 ml, 0.11 mol) was slowly added dropwise. The reaction mixture was stirred at 0° C. for a further 30 minutes and subsequently at room temperature for 2 hours. Conventional work-up gave 3.46 g (48% yield) of (6-methoxypyridazin-3-yl)pyrdin-3-ylmethanone;

Provenance & Evidence