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HRID714783

反应详情

EQUATION

反应方程式

HRID 714783 的结构方程式

REACTANTS

反应物

2
结构：CC#N.CO.O=C=O
HCID86678958

未命名化合物

结构：CCC1(C#N)CCN(c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)C1=O
HCID117840450

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@]1(C#N)CCN(c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)C1=O
HCID117840463

未命名化合物

收率 23.5%

PROCEDURE

实验过程

3-Ethyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile (200 mg) obtained in Example 2 was resolved by SFC (column: CHIRALCEL OJH, 20 mmID×250 mmL, manufactured by Daicel Chemical Industries, mobile phase: carbon dioxide/methanol/acetonitrile=660/170/170), and the compound having a shorter retention time was recrystallized (hexane/ethyl acetate) to give the title compound (47 mg).

WORKUP

后处理

  1. customwas recrystallized (hexane/ethyl acetate)