CO2 Methanol MeCN → (3R)-3-ethyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	CO2 Methanol MeCN	HCID 86678958	—
Reactant	3-Ethyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile	HCID 117840450	—
Product	(3R)-3-ethyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile	HCID 117840751	29%

Reaction Steps

3-Ethyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile (200 mg) obtained in Example 2 was resolved by SFC (column: CHIRALCEL OJH, 20 mmID×250 mmL, manufactured by Daicel Chemical Industries, mobile phase: carbon dioxide/methanol/acetonitrile=660/170/170), and the compound having a longer retention time was recrystallized (hexane/ethyl acetate) to give the title compound (58 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09187453B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-9e6b23bf43494d388c1dbdcae68f74f4
Source note	uspto-grants-2015_11