huagongshe.com
HRID714789

反应详情

EQUATION

反应方程式

HRID 714789 的结构方程式

REACTANTS

反应物

2
结构：CC#N.CO.O=C=O
HCID86678958

未命名化合物

结构：CC(C)C1(C#N)CCN(c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)C1=O
HCID117840313

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@@]1(C#N)CCN(c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)C1=O
HCID117840345

未命名化合物

收率 15.3%

PROCEDURE

实验过程

3-Isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile (85 mg) obtained in Example 5 was resolved by SFC (column: CHIRALCEL OJH, 20 mmID×250 mmL, manufactured by Daicel Chemical Industries, mobile phase: carbon dioxide/methanol/acetonitrile=660/170/170), and the compound having a shorter retention time was recrystallized (hexane/ethyl acetate) to give the title compound (13 mg).

WORKUP

后处理

  1. customwas recrystallized (hexane/ethyl acetate)