反应详情

A solution of (3S)-1-(2-chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrile (55 mg) obtained in Step A, 4-amino-N-methylbenzamide (37 mg) and acetic acid (13 μL) in ethanol (2 mL) was stirred in a microwave reactor at 150° C. for 1 hr, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate). To a solution of the residue (87 mg) in ethanol (3 mL) was added 1M hydrochloric acid (230 μL), and the solvent was evaporated under reduced pressure. The residue was recrystallized (diisopropyl ether/ethanol) to give the title compound (65 mg).

1. customthe solvent was evaporated under reduced pressure
2. customThe obtained residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate)
3. additionTo a solution of the residue (87 mg) in ethanol (3 mL) was added 1M hydrochloric acid (230 μL)
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was recrystallized (diisopropyl ether/ethanol)