Cesium carbonate → HCID 90459555, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2,4-dichloropyrimidine (2.6 g), pyrrolidin-2-one (1.0 g), cesium carbonate (11 g) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (370 mg) in toluene (10 mL) was added tris(dibenzylideneacetone)dipalladium(0) (540 mg), and the mixture was stirred in a microwave reactor at 110° C. for 1.5 hr. The insoluble substance was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (370 mg).

Provenance & Evidence