反应详情

To a stirred solution of 3-hydroxypicolinic acid (0.7122 g, 5.1 mmol) in CH3OH (32 mL) at room temperature was added concentrated H2SO4 (4 mL). The mixture was heated to reflux for 18 hrs then concentrated. The residue was diluted with saturated aqueous Na2CO3 (45 mL) and extracted with CH2Cl2 (4×30 mL). The combined organic phases were dried (Na2SO4) and concentrated to give 0.73 g 3-hydroxypicolinic acid methyl ester as a white powder.

1. temperatureThe mixture was heated
2. temperatureto reflux for 18 hrs
3. concentrationthen concentrated
4. additionThe residue was diluted with saturated aqueous Na2CO3 (45 mL)
5. extractionextracted with CH2Cl2 (4×30 mL)
6. dry with materialThe combined organic phases were dried (Na2SO4)
7. concentrationconcentrated