Potassium Carbonate → Ethyl(3-ethyl-2-oxopyrrolidin-3-yl)acetate

Participants

Reaction Steps

To a solution of ethyl(3-ethyl-1-(4-methoxybenzyl)-2-oxopyrrolidin-3-yl)acetate (1.5 g) obtained in Step C in a mixed solvent of acetonitrile/water (3/1, 8 mL) was added ammonium hexanitratocerate(IV) (5.2 g), and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added potassium carbonate, the solid was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (900 mg).

Provenance & Evidence