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HRID714821

反应详情

EQUATION

反应方程式

HRID 714821 的结构方程式

REACTANTS

反应物

1
结构：N#CC1(C2CC2)CCN(c2ccnc(Cl)n2)C1=O
HCID117839802

未命名化合物

PRODUCTS

生成物

1
结构：N#C[C@]1(C2CC2)CCN(c2ccnc(Cl)n2)C1=O
HCID117840658

3-Pyrrolidinecarbonitrile, 1-(2-chloro-4-pyrimidinyl)-3-cyclopropyl-2-oxo-, (3R)-

C12H11ClN4O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O.CCCCCC
溶剂HCID21585144

未命名化合物

PROCEDURE

实验过程

1-(2-Chloropyrimidin-4-yl)-3-cyclopropyl-2-oxopyrrolidine-3-carbonitrile (23 g) obtained in Step D of Example 103 was resolved by HPLC (column: CHIRALPAK IC, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/2-propanol=200/800) to give the title compound (11 g: a longer retention time).