Hydrochloric Acid → HCID 117840009, compound

Participants

Reaction Steps

To tert-butyl(1-(2-methyl-1-(methylsulfonyl)propan-2-yl)-1H-pyrazol-4-yl)carbamate (250 mg) obtained in Step C of Example 114 was added dropwise a solution of 4 M hydrogen chloride in ethyl acetate (4.0 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (23 mg).

Provenance & Evidence