(1-(4-nitro-1H-pyrazol-1-yl)cyclopropyl)methanol → (1-(4-amino-1H-pyrazol-1-yl)cyclopropyl)methanol

HRID 714842Notes

Reaction equation

HRID 714842 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2([CH2:12][OH:13])[CH2:11][CH2:10]2)[CH:8]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]2([CH2:12][OH:13])[CH2:10][CH2:11]2)[CH:8]=1

Participants

3

Reactant 1

HCID 91619134(1-(4-nitro-1H-pyrazol-1-yl)cyclopropyl)methanol

Product 1

HCID 91618623(1-(4-amino-1H-pyrazol-1-yl)cyclopropyl)methanolYield 99.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (1-(4-nitro-1H-pyrazol-1-yl)cyclopropyl)methanol (300 mg) obtained in Step B of Example 128 in ethanol (20 mL) was added palladium-activated carbon ethylene diamine complex (Pd: 8.5-11.5%) (100 mg), and the mixture was stirred at room temperature for 5 hr under hydrogen atmosphere (at normal pressures). The palladium-activated carbon ethylene diamine complex was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (250 mg).

Workup

  1. customThe palladium-activated carbon ethylene diamine complex was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cad7d34869794f2182cd48a55ac0f298
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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