Tert-butyl 2-ethoxy-4-nitrobenzoate → Tert-butyl 4-amino-2-ethoxybenzoate

Participants

Reaction Steps

To a solution of tert-butyl 2-ethoxy-4-nitrobenzoate (550 mg) obtained in Step B of Example 139 in ethanol (10 mL) was added 10% palladium-carbon (42 mg), and the mixture was stirred overnight at room temperature under hydrogen atmosphere (at normal pressures). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (470 mg).

Provenance & Evidence