反应详情

To a solution of ethyl 1-(4-nitrophenyl)cyclopropanecarboxylate (3.0 g) obtained in Step A of Example 145 in ethanol (50 mL) was added 1M aqueous sodium hydroxide solution (25 mL), and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure, and 1M hydrochloric acid was added thereto at 0° C. The resulting solid was collected by filtration to give the title compound (2.5 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure, and 1M hydrochloric acid
2. additionwas added
3. customat 0° C
4. filtrationThe resulting solid was collected by filtration