Acetic Acid → 1-(4-((4-((3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxylic acid hydrochloride

Participants

Reaction Steps

A solution of (3S)-1-(2-chloropyrimidin-4-yl)-3-cyclopropyl-2-oxopyrrolidine-3-carbonitrile (100 mg) obtained in Step E of Example 103, 1-(4-aminophenyl)cyclopropanecarboxylic acid (67 mg) obtained in Step C of Example 145 and acetic acid (30 μL) in 2-propanol (1.5 mL) was stirred in a microwave reactor at 150° C. for 1 hr, and the resulting solid was collected by filtration to give the title compound (130 mg).

Provenance & Evidence