Hydrogen Peroxide → HCID 117841131, compound

Participants

Reaction Steps

To a solution of 4-(4-aminophenyl)tetrahydro-2H-pyran-4-carbonitrile (500 mg) obtained in Step B of Example 150 and potassium carbonate (1.0 g) in dimethylsulfoxide (10 mL) was added 30% aqueous hydrogen peroxide (0.65 mL), and the mixture was stirred at room temperature for 10 hr. To the reaction mixture was added saturated aqueous sodium thiosulfate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (380 mg).

Provenance & Evidence