Sodium sulfate decahydrate → HCID 117840022, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of lithium aluminium hydride (300 mg) in tetrahydrofuran (20 mL) was added dropwise a solution of ethyl 4-(4-nitrophenyl)tetrahydro-2H-pyran-4-carboxylate (1.0 g) obtained in Step A of Example 151 in tetrahydrofuran (10 mL) at −78° C., and the mixture was stirred at 0° C. for 1 hr. To the reaction mixture was added sodium sulfate decahydrate, and the mixture was stirred at room temperature for 2 hr. The insoluble substance was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (330 mg).

Provenance & Evidence