Hydrochloric Acid → HCID 117840128, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-(4-((4-((3R)-3-cyano-3-ethyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropanoate (1.0 g) obtained in Step A of Example 199 in ethyl acetate (10 mL) was added a solution of 4 M hydrogen chloride in ethyl acetate (10 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the residue was recrystallized (ethanol/diisopropyl ether) to give the crude title compound (820 mg). The crude title compound (100 mg) was purified by HPLC (C18, mobile phase: water/acetonitrile (containing 10 mM NH4HCO3)), and the solvent was evaporated under reduced pressure. To a solution of the residue in ethanol (3 mL) was added 1 M hydrochloric acid (0.20 mL), and the mixture was stirred at room temperature for 10 min. The solvent was evaporated under reduced pressure, and the residue was recrystallized (ethanol/diisopropyl ether) to give the title compound (820 mg).

Provenance & Evidence