Potassium Phosphate, Tribasic → HCID 117841056, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 2-bromo-4-nitrobenzoate (1.5 g) obtained in Step A of Example 301 in a mixed solvent of toluene-water (v/v=5/1, 18 mL) were successively added cyclopropylboronic acid (1.3 g), tripotassium phosphate (4.7 g), tricyclohexyl phosphine (280 mg) and palladium acetate (110 mg), and the mixture was stirred overnight at 100° C. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (1.3 g).

Provenance & Evidence