2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 714930Notes

Reaction equation

HRID 714930 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Participants

5

Reactant 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Product 1

HCID 23698872Sodium 2,6-difluorobenzoateYield 100%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-42caf2d19a924c09b8ec9a72668f2496
Source dataset
uspto-grants-2015_11
Patent number
US09187465B2

Reaction notes

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