HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714959Generated: October 30, 2026
Hydrochloric Acid → 5-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid
https://huagongshe.com/reaction/714959
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate | HCID 68518280 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid | HCID 29281463 | — |
Reaction Steps
To a solution of ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate in MeOH (2 mL) and DCM (0.5 mL) was added 1M aqueous lithium hydroxide solution (2 mL, 2 mmol). The reaction mixture was stirred at 50° C. overnight and then 2M aqueous HCl (0.125 mL) was added and the solvent removed in vacuo to afford 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187465B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-a49e6059fff34e4783bb69925901d559 |
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| Source note | uspto-grants-2015_11 |
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