HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2,6-difluorophenyl)-5-ethoxy-N-phenyloxazole-4-carboxamide → Ethyl 2-(2,6-difluorophenyl)-5-(phenylamino)oxazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2,6-difluorophenyl)-5-ethoxy-N-phenyloxazole-4-carboxamide | HCID 59587484 | — |
| Solvent | (Trifluoromethyl)benzene | HCID 7368 | — |
| Product | Ethyl 2-(2,6-difluorophenyl)-5-(phenylamino)oxazole-4-carboxylate | HCID 59587399 | 99.4% |
Reaction Steps
A solution of 2-(2,6-difluorophenyl)-5-ethoxy-N-phenyloxazole-4-carboxamide (0.13 g, 0.38 mmol) in trifluorotoluene was heated at 180° C. for 5 minutes in the microwave. The solvent was removed in vacuo to give ethyl 2-(2,6-difluorophenyl)-5-(phenylamino)oxazole-4-carboxylate (0.13 g) as a brown solid which was used without further purification. LCMS (1) Rt: 2.40 min; m/z (ES+) 345.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187465B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-9885a8355fb543509044b2caf0a2184e |
| Source note | uspto-grants-2015_11 |