2H-pyran-4-amine → HCID 71529653, compound

Participants

Reaction Steps

(S)-5-Fluoro-N-((3-fluoro-4-methoxyphenyl)(2-methyl-2H-1,2,3-triazol-4-yl)methyl)-2-(tetrahydro-2H-pyran-4-ylamino)quinazoline-7-carboxamide (I-51) was prepared analogously except 32b was replaced with 34c, and 5-fluoro-N-((S)-(3-fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-4-yl)methyl)-2-((3S,4S)-3-fluorotetrahydro-2H-pyran-4-ylamino)quinazoline-7-carboxamide (I-52) was prepared analogously except 84b was replaced with 5-fluoro-2-((3S,4S)-3-fluorotetrahydro-2H-pyran-4-ylamino)quinazoline-7-carboxamide which can be prepared in accord with the procedure in example 3 except in step 3, 2H-pyran-4-amine was replaced with 60c.

Provenance & Evidence