HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5)-(3-Fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-4-yl)methanamine → 2-(Cyclopropylmethyl-amino)-5-fluoro-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5)-(3-Fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-4-yl)methanamine | HCID 71247008 | — |
| Reactant | 2-(Cyclopropylmethylamino)-5-fluoroquinazoline-7-carboxylic acid | HCID 71247027 | — |
| Product | 2-(Cyclopropylmethyl-amino)-5-fluoro-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide | HCID 71529214 | — |
Reaction Steps
The condensation of 2-(cyclopropylmethylamino)-5-fluoroquinazoline-7-carboxylic acid and (S)-(3-fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-4-yl)methanamine (401) to afford I-60 was carried out in accord with the procedure in Example 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187462B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7cb77bf0fa9b44028f8166830cebaf55 |
| Source note | uspto-grants-2015_11 |