反应详情

Treat a 0° C. solution of 4-fluorophenylacetic acid (3 g, 19.46 mmol) in H2SO4 (20 mL) drop wise with nitric acid (0.913 mL, 20.44 mmol) and stir for 1 h. Pour the mixture onto ice, extract with DCM (2×), wash the combined organics with brine, dry over MgSO4 and concentrate to dryness to afford the title compound (3.48 g, 90%). MS (ESI) m/z: 198.1 (M−H+).

1. additionPour the mixture onto ice
2. extractionextract with DCM (2×)
3. washwash the combined organics with brine
4. dry with materialdry over MgSO4
5. concentrationconcentrate to dryness